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Drug Therapy for Rheumatoid Arthritis in Adults
Authors: John I. Gomez, MD
Clinically Significant Outcomes of Interest in the Comparative Effectiveness Review
In analyzing the clinical study evidence, reviewers focused on these outcomes of benefit and corresponding assessment instruments or scoring indices:
- Disease activity and symptoms were evaluated using American College of Rheumatology response scores (ACR 20/50/70) and DAS and DAS28 disease activity scores.
- Radiographic changes were measured using the Sharp/van der Heijde Method (SHS) for scoring radiographs.
- Functional capacity was evaluated by the Health Assessment Questionnaire (HAQ) and the disability index of HAQ (HAQ-DI).
- Quality of life was measured using the SF-36 and EQ-5D questionnaires.
Keywords: rheumatoid arthritis | RA | DMARDs | disease-modifying | antirheumatic | anti-rheumatic | rheumatic | biologic | oral | disease activity | ACR | radiographic evidence of progression | functional capacity | HAQ | quality of life | SF-36 | DAS
- Donahue KE, Jonas D, Hansen RA, et al. Drug Therapy for Rheumatoid Arthritis in Adults: An Update. Comparative Effectiveness Review No. 55 (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2007-10056-I). Rockville, MD: Agency for Healthcare Research and Quality; April 2012. AHRQ Publication No. 12-EHC025-EF. Available at www.effectivehealthcare.ahrq.gov/dmardsra.cfm.
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