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Noninvasive Positive-Pressure Ventilation for Acute Respiratory Failure: Comparative Effectiveness

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Gaps in Knowledge (2 of 2)

Other knowledge gaps in the current literature on the use of noninvasive positive-pressure ventilation (NPPV) in patients with acute respiratory failure of various etiologies include:

  • The studies assessing NPPV in patients with acute respiratory failure included in this review provided little or no information on study results by patient characteristics such as body mass index, mental status, or overall disease burden. The impact of patient characteristics on the effects of NPPV therefore remain uncertain.
  •  The included studies also provided limited information on outcomes such as patient psychological status, quality of life, and functional status and on resource utilization.
  •  The effectiveness of NPPV as implemented in routine clinical practice remains unclear. Additionally, it is unclear how clinician training, hospital staffing composition and ratios, and the use of treatment algorithms impact NPPV effectiveness.

Future research studies should aim to address these gaps.