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Noninvasive Positive-Pressure Ventilation for Acute Respiratory Failure: Comparative Effectiveness

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Gaps in Knowledge (1 of 2)

The review identified several knowledge gaps in the current literature on the use of noninvasive positive-pressure ventilation (NPPV) in patients with acute respiratory failure of various etiologies which include:

  • A limited number of studies assessed the effects of NPPV versus supportive care in patients with asthma, interstitial lung disease, pneumonia, acute respiratory distress syndrome/acute lung injury, or obesity hypoventilation syndrome and in patients who had undergone transplantation or other surgeries. The evidence is therefore insufficient to allow meaningful conclusions about the effects of NPPV in patients with acute respiratory failure of these etiologies.
  • There is some uncertainty about the benefits of NPPV in facilitating extubation or in preventing recurrent acute respiratory failure after extubation due to the limited amount of evidence in this area.