Noninvasive Positive-Pressure Ventilation for Acute Respiratory Failure: Comparative Effectiveness
Conclusions (1 of 2)
For patients with acute respiratory failure due to severe exacerbations of chronic obstructive pulmonary disease or acute cardiogenic pulmonary edema (ACPE), the use of noninvasive positive-pressure ventilation (NPPV) plus supportive medical therapy was associated with reductions in mortality, intubation rates, and hospital-acquired pneumonia when compared with supportive medical therapy alone.
In a limited number of patients, the use of NPPV decreased hospital-acquired pneumonia when compared with invasive ventilation.
- Williams JW Jr, Cox CE, Hargett CW, et al. Noninvasive Positive-Pressure Ventilation (NPPV) for Acute Respiratory Failure: Comparative Effectiveness. Comparative Effectiveness Review No. 68 (Prepared by the Duke Evidence-based Practice Center under Contract No. 290-2007-10066-I). Rockville, MD: Agency for Healthcare Research and Quality; July 2012. AHRQ Publication No. 12-EHC089-EF. Available at www.effectivehealthcare.ahrq.gov/nppv.cfm.
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