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Noninvasive Positive-Pressure Ventilation for Acute Respiratory Failure: Comparative Effectiveness

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Noninvasive Positive-Pressure Ventilation for Acute Respiratory Failure: Comparative Effectiveness

This slide set is based on a comparative effectiveness review (CER) titled Noninvasive Positive-Pressure Ventilation (NPPV) for Acute Respiratory Failure: Comparative Effectiveness, Comparative Effectiveness Review No. 68, which was developed by the Duke Evidence-based Practice Center, Durham, NC, for the Agency for Healthcare Research and Quality (AHRQ) under Contract No. 290-2007-10066-I and is available online at www.effectivehealthcare.ahrq.gov/nppv.cfm.

CERs are comprehensive systematic reviews of the literature that usually compare two or more types of interventions with usual care for the same disease. For this CER, the existing body of evidence on the relative benefits and adverse effects of currently used modalities of noninvasive positive-pressure ventilation (NPPV) was reviewed. The literature included in this review was identified in searches for studies in MEDLINE®, EMBASE®, and the Cochrane Database of Systematic Reviews using relevant search terms. Studies in adults with acute respiratory failure due to chronic obstructive pulmonary disease, acute cardiogenic pulmonary edema, pneumonia, asthma, obesity hypoventilation syndrome, interstitial lung disease, and acute respiratory failure in the postoperative and post-transplantation settings were included. The review did not include children or adults in whom NPPV is contraindicated (patients with facial trauma, cardiopulmonary arrest, or shock) in its evaluation. Searches were conducted for studies published in the English language from 1990 onwards.