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Disease-Modifying Antirheumatic Drugs in Children With Juvenile Idiopathic Arthritis

Slide: 7 of 46

DMARDs for Treating JIA (1 of 2)

Nonbiologic, synthetic DMARDs are small-molecule chemical drugs. The mechanism of action of each of these drugs is not well defined and is unknown in some cases.

Biologic DMARDs are genetically engineered antibodies and proteins that block the activity of immunostimulatory cytokines and other cell-signaling molecules. The tumor necrosis factor-alpha (TNF-α) blockers are the most typical members of this drug class. Other targets are interleukins 1 and 6 and the transmembrane proteins CD20 and CD28.