Disease-Modifying Antirheumatic Drugs in Children With Juvenile Idiopathic Arthritis
Results From Evaluation of JIA Assessment Instruments (1 of 2)
Active joint count was evaluated in 12 studies with a combined total of 8,064 patients. Validity was moderate for functional status but poor for psychosocial aspects of quality of life. Responsiveness was high. No data were found regarding reliability. Physician Global Assessment of Disease Activity was evaluated in 12 studies with a combined total of 8,668 patients. Validity analysis showed moderate correlation with the Childhood Health Assessment Questionnaire, quality-of-life measures, and disease-activity measurements. No data were available regarding reliability scores; responsiveness is difficult to measure with this tool. Parent/patient assessments of well-being were evaluated in eight studies with a combined total of 8,182 patients. Validity evaluation revealed moderate correlations with the Childhood Health Assessment Questionnaire, physical aspects of quality-of-life measures, and disease-activity measurements. Poor correlation was found with the psychosocial aspects of quality of life. Reliability and responsiveness were both scored as moderate.
Keywords: active joint count | AJC | anti-rheumatic | antirheumatic | assessment | biologic DMARD | disease-modifying | DMARDs | JCA | JIA | JRA | juvenile rheumatoid arthritis | non-biologic DMARD | nonbiologic DMARD | parent assessment of well-being | PGA | PGW | physician global assessment | reliability | responsiveness | rheumatic | TNF-alpha blockers | validity | juvenile idiopathic arthritis
- Kemper A, Coeytaux R, Sanders G, et al. Disease-Modifying Antirheumatic Drugs (DMARDs) in Children With Juvenile Idiopathic Arthritis (JIA). Comparative Effectiveness Review No. 28 (Prepared by the Duke Evidence-based Practice Center under Contract No. HHSA 290-2007-10066-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC039-EF. Available at www.effectivehealthcare.ahrq.gov/dmardsjia.cfm.
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