Disease-Modifying Antirheumatic Drugs in Children With Juvenile Idiopathic Arthritis
Adverse Effects Associated With DMARDs
Both nonbiologic and biologic DMARDs are associated with known risks for adverse effects. Among the nonbiologic DMARDs, these include nausea and other gastrointestinal upset, skin rashes, organ toxicity, and elevated risk of serious infections. Biologic DMARDs also carry increased risk of serious infections, along with allergic and hypersensitivity reactions, and are suspected of elevating the risk of lymphoma and other malignancies.
Keywords: adverse effects | adverse effects | malignancies | organ toxicity | toxicity | infections | rashes | gastrointestinal upset | hypersensitivity
- Kemper A, Coeytaux R, Sanders G, et al. Disease-Modifying Antirheumatic Drugs (DMARDs) in Children With Juvenile Idiopathic Arthritis (JIA). Comparative Effectiveness Review No. 28 (Prepared by the Duke Evidence-based Practice Center under Contract No. HHSA 290-2007-10066-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC039-EF. Available at www.effectivehealthcare.ahrq.gov/dmardsjia.cfm.
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