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Disease-Modifying Antirheumatic Drugs in Children With Juvenile Idiopathic Arthritis

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Adverse Effects Associated With DMARDs

Both nonbiologic and biologic DMARDs are associated with known risks for adverse effects. Among the nonbiologic DMARDs, these include nausea and other gastrointestinal upset, skin rashes, organ toxicity, and elevated risk of serious infections. Biologic DMARDs also carry increased risk of serious infections, along with allergic and hypersensitivity reactions, and are suspected of elevating the risk of lymphoma and other malignancies.