Off-Label Use of Atypical Antipsychotics: An Update
Introduction to Atypical Antipsychotics (1 of 4)
Antipsychotics can be classified into two categories, based on the timeline of their development, pharmacology, and anticipated adverse effects profiles. The groups are the typical antipsychotics, also called conventional or first generation, and the atypical antipsychotics, also called second generation. Typical antipsychotics were the first successful pharmacological treatments for primary psychotic disorders such as schizophrenia. However, they are associated with side effects that are difficult to manage and, in some cases, irreversible. Atypical antipsychotics were developed in response to avoiding these adverse effects.
- Maglione M, Ruelaz Maher A, Hu J, et al. Off-Label Use of Atypical Antipsychotics: An Update. Comparative Effectiveness Review No. 43 (Prepared by the Southern California RAND Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11(12)-EHC087-EF. Available at www.effectivehealthcare.ahrq.gov/offlabelantipsych.cfm.
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