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Off-Label Use of Atypical Antipsychotics: An Update

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Summary of Benefits: Atypical Antipsychotics for Obsessive-Compulsive Disorder

Risperidone improves symptoms of obsessive-compulsive disorder when used as an adjunct to selective serotonin reuptake inhibitors (SSRIs) for patients whose symptoms are refractory to treatment. The strength of evidence in support of this finding is moderate. Olanzapine and risperidone are similar in effect for augmenting SSRIs. The strength of evidence in support of this finding is low.