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Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations

Slide: 21 of 23

Conclusions (2 of 2)

Because the methodological limitations of existing studies prevent further assessment of the sensitivity and specificity of the ANA, RF, and CCP serological tests, their use as diagnostic tests or for broad screening remains unsupported. These serological tests have potential use only as an adjunct to a clinical assessment that suggests the presence of an inflammatory arthritis or connective tissue disease.

ANA = antinuclear antibody
CCP = cyclic-citrullinated peptide
RF = rheumatoid factor