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Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations

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Conclusions (1 of 2)

The prevalence of MSK pain varies with age and sex. Most MSK pain in children (97%) results from noninflammatory causes. A review of the patient’s history and performance of an MSK examination remain the most appropriate methods for diagnosing rheumatic etiologies of pediatric MSK pain in a timely fashion. The use of laboratory tests (i.e., ANA, RF, and CCP) as diagnostic measures or for broad screening of pediatric rheumatic conditions remains unsupported.

Abbreviations:
ANA = antinuclear antibody
CCP = cyclic-citrullinated peptide
JIA = juvenile idiopathic arthritis
MSK = musculoskeletal
pSLE = pediatric systemic lupus erythematosus
RF = rheumatoid factor