Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing for the Evaluation of Musculoskeletal Complaints in Pediatric Populations
Conclusions (1 of 2)
The prevalence of MSK pain varies with age and sex. Most MSK pain in children (97%) results from noninflammatory causes. A review of the patient’s history and performance of an MSK examination remain the most appropriate methods for diagnosing rheumatic etiologies of pediatric MSK pain in a timely fashion. The use of laboratory tests (i.e., ANA, RF, and CCP) as diagnostic measures or for broad screening of pediatric rheumatic conditions remains unsupported.
ANA = antinuclear antibody
CCP = cyclic-citrullinated peptide
JIA = juvenile idiopathic arthritis
MSK = musculoskeletal
pSLE = pediatric systemic lupus erythematosus
RF = rheumatoid factor
Keywords: adolescents | age | children | clinical assessment | juvenile idiopathic arthritis | noninflammatory pain | prevalence | sex | test sensitivity | test specificity | musculoskeletal pain
- Wong KO, Bond K, Homik J, et al. Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Tests for Evaluating Musculoskeletal Complaints in Children. Comparative Effectiveness Review No. 50 (Prepared by the University of Alberta Evidence-based Practice Center under Contract No. HHSA 290-2007-10021-I). Rockville, MD: Agency for Healthcare Research and Quality; March 2012. AHRQ Publication No. 12-EHC015-EF. Available at www.effectivehealthcare.ahrq.gov/anatest.cfm.
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