Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update
Findings of the Comparative Effectiveness Review: Endoscopic Treatments (1 of 2)
Recently, endoscopic treatments have been proposed to reduce the need for long-term use of acid-reducing medications in patients with GERD. The original 2005 review on GERD treatments evaluated studies on four endoscopic procedures: the EndoCinch™ Suturing System, Stretta®, Enteryx™, and the NDO Plicator™. The present updated report excluded Enteryx and the NDO Plicator because they are no longer available in the United States. Stretta was removed from the market but reintroduced in 2010 by a separate manufacturer. Another device, EsophyX™, was commercialized after the original review. Evidence of low strength yielded mixed results regarding the effectiveness of the endoscopic treatment EndoCinch for improving symptoms, quality of life, and healing of esophagitis.
No studies directly comparing endoscopic treatments were identified for this update; however, a number of sham-controlled and cohort studies examining the effectiveness of the individual procedures were reviewed.
GERD = gastroesophageal reflux disease
Keywords: GERD | H2RA | histamine type 2 receptor antagonist | PPI | proton pump inhibitor | surgery | fundoplication
- Ip S, Chung M, Moorthy D, et al. Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update. Comparative Effectiveness Review No. 29 (Prepared by the Tufts Evidence-based Practice Center under Contract No. HHSA 290-2007-10055-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC049-EF. Available at www.effectivehealthcare.ahrq.gov/gerdupdate.cfm.
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