Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update
Findings of the Comparative Effectiveness Review: Medication (2 of 3)
Evidence of moderate strength indicates that continuous therapy with a PPI appeared to be more effective than on-demand therapy for symptom control in patients with GERD. Evidence of moderate strength also indicates that obesity, severity of baseline symptoms, and severe baseline esophagitis were significantly associated with worse outcomes from treatment with medication, but older age was associated with improved symptom control at 6 months. Evidence of low strength indicates that PPIs demonstrate no difference from placebo in resolving hoarseness but do demonstrate some improvement inconsistently in resolving cough. Evidence was insufficient concerning the effectiveness of GERD treatment for relieving asthma symptoms.
GERD = gastroesophageal reflux disease
PPI = proton pump inhibitor
Keywords: GERD | histamine type 2 receptor antagonist | H2RA | proton pump inhibitor | PPI | extraesophageal
- Ip S, Chung M, Moorthy D, et al. Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update. Comparative Effectiveness Review No. 29 (Prepared by the Tufts Evidence-based Practice Center under Contract No. HHSA 290-2007-10055-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC049-EF. Available at www.effectivehealthcare.ahrq.gov/gerdupdate.cfm.
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