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Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update

Slide: 15 of 26

Findings of the Comparative Effectiveness Review: Medication (1 of 3)

Many patients with GERD have frequent, severe symptoms that require long-term, regular use of acid-reducing medications. Depending on the severity of symptoms and clinical response, intermittent (on-demand), periodic, or continuous use of prescription or over-the-counter medications, especially H2RAs and PPIs, may be used. Evidence of moderate strength indicates that PPIs were superior to H2RAs for esophagitis healing, patient satisfaction and compliance, and symptom remission. This evidence also indicates that all of the commercially available PPIs appeared to be similarly effective for relieving symptoms and healing esophagitis for up to 1 year.

GERD = gastroesophageal reflux disease
H2RA = histamine type 2 receptor antagonist
PPI = proton pump inhibitor