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Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update

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Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update

This slide set is based on a comparative effectiveness review (CER) titled Comparative Effectiveness of Management Strategies for Adults With Gastroesophageal Reflux Disease: An Update, which was developed by the Tufts Evidence-based Practice Center, Tufts Medical Center, Boston, MA, for the Agency for Healthcare Research and Quality (AHRQ) under Contract No. HHSA 290-2007-10055-I and is available online at www.effectivehealthcare.ahrq.gov/gerdupdate.cfm.

CERs are comprehensive systematic reviews of the literature that usually compare two or more types of treatment with usual care for the same disease. For this CER, the existing body of evidence on the comparative benefits and possible harms of different interventions used to treat gastroesophageal reflux disease (GERD) were reviewed. The literature included in this review was identified in searches for trials and studies that included terms for GERD and relevant research designs. Only studies on adults (≥18 years of age) were included. Searches were conducted for studies published through August 2010. Of note, with the exception of a noted correlation between obesity and some treatment-related outcomes, behavioral modifications to ameliorate GERD symptoms are not discussed in the CER (e.g., smoking cessation, addressing anxiety, or alcohol intake).