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Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update

Slide: 37 of 40

Gaps in Knowledge (1 of 3)

Evidence is insufficient to evaluate potential associations between bisphosphonate use and either esophageal cancer or atrial fibrillation. However, an FDA safety review notes that a relationship between zoledronic acid and atrial fibrillation is still an area of active surveillance, though an association is unproven.

Evidence for the antifracture effects of currently available osteoporosis therapies is greatest among patients with established osteoporosis, and few head-to-head comparisons of medications exist. Studies comparing exercise with medications are lacking.