Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update
Treatment Monitoring, Adherence, and Persistence (3 of 3)
Observational studies show that adherence to therapy with bisphosphonates is improved with weekly compared with daily regimens. (Evidence is lacking to evaluate comparative adherence to monthly versus weekly regimens.) The strength of evidence for this finding is high.
Observational studies show that other factors affecting adherence and persistence include, but are not limited to, dosing frequency, side effects of medications, comorbid conditions, knowledge about osteoporosis, and medication cost.
Age, previous history of fracture, and concomitant medication use do not appear to affect adherence or persistence. The strength of evidence for this finding is moderate.
Keywords: bone | low bone density | bone density | osteoporosis | fracture | osteopenia | skeletal | bisphosphonate | adherence | dosing | comorbid | age
- Newberry SJ, Crandall CC, Gellad WG, et al. Treatment To Prevent Fractures in Men and Women Low Bone Density or Osteoporosis: An Update to the 2007 Report. Comparative Effectiveness Review No. 53 (Prepared by the Southern California Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; February 2012. AHRQ Publication No. 12-EHC023-EF. Available at www.effectivehealthcare.ahrq.gov/reports/lbd.cfm.
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