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Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update

Slide: 34 of 40

Treatment Monitoring, Adherence, and Persistence (3 of 3)

Observational studies show that adherence to therapy with bisphosphonates is improved with weekly compared with daily regimens. (Evidence is lacking to evaluate comparative adherence to monthly versus weekly regimens.) The strength of evidence for this finding is high.

Observational studies show that other factors affecting adherence and persistence include, but are not limited to, dosing frequency, side effects of medications, comorbid conditions, knowledge about osteoporosis, and medication cost.

Age, previous history of fracture, and concomitant medication use do not appear to affect adherence or persistence. The strength of evidence for this finding is moderate.