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Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update

Slide: 33 of 40

Treatment Monitoring, Adherence, and Persistence (2 of 3)

Decreased adherence to bisphosphonates is associated with an increased risk of fracture (vertebral, nonvertebral, or both). The strength of evidence is moderate.

In general, RCTs examining bisphosphonates report high levels of adherence (majority over 90%), and trials with raloxifene had adherence rates of 65 to 70 percent. The strength of evidence is moderate.

Observational studies of patients taking bisphosphonates in combination with calcium and vitamin D, however, show that adherence and persistence is poor in many patients. The strength of evidence is high.