Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update
Benefits of Medications in Subpopulations
Patients with high risk for fracture (including postmenopausal women with osteoporosis) are likely to benefit from alendronate, denosumab, ibandronate, risedronate, teriparatide, raloxifene, and zoledronic acid. The strength of evidence for these findings is high.
Patients treated with glucocorticoids are likely to benefit from alendronate, risedronate, and teriparatide. The strength of evidence for these findings is low to moderate.
Patients with a higher risk of falling (e.g., patients with hemiplegia, Alzheimer’s disease, or Parkinson’s disease) are likely to benefit from alendronate, risedronate, and vitamin D. The strength of evidence for these findings is moderate.
For transplant recipients and patients treated chronically with corticosteroids, there is inconclusive support for any agent, and the evidence is insufficient to permit conclusions.
The risk of fragility fracture is reduced in postmenopausal women with osteopenia who do not have prevalent vertebral fractures when treated with risendronate. The strength of evidence for this finding is low to moderate.
Keywords: bone | low bone density | bone density | osteoporosis | fracture | osteopenia | skeletal | FRAX | glucocorticoids | risk | corticosteroids | osteopenia | vertebral | alendronate | ibandronate | risedronate | zoledronic acid | denosumab | teriparatide | raloxifene | bisphosphonates | vitamin D | risedronate | fragility fracture
- Newberry SJ, Crandall CC, Gellad WG, et al. Treatment To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis: An Update to the 2007 Report. Comparative Effectiveness Review No. 53 (Prepared by the Southern California Evidence-based Practice Center under Contract No. HHSA 290-2007-10062-I). Rockville, MD: Agency for Healthcare Research and Quality; February 2012. AHRQ Publication No. 12-EHC023-EF. Available at www.effectivehealthcare.ahrq.gov/reports/lbd.cfm.
Your slide tray is being processed.