Non-surgical Treatments for Urinary Incontinence in Adult Women: Diagnosis and Comparative Effectiveness
Modifiers of Outcomes and Safety of Pharmacological Treatment (1 of 2)
Age does not modify continence or improvement outcomes of oxybutynin, trospium, or darifenacin. The strength of evidence for these findings is moderate.
Obesity does not modify the effect of trospium. The strength of evidence for this finding is high.
Solifenacin is effective regardless of response to previous treatment, but patients whose symptoms respond poorly do not benefit from increasing the dose of the drug. The strength of evidence for this finding is high.
Concomitant medications do no affect trospium effectiveness, but adverse effects are more common in patients taking trospium and seven or more concomitant medications. The strength of evidence for this finding is moderate.
Keywords: Urinary incontinence | stress incontinence | urge incontinence | urgency incontinence | mixed incontinence | continence | pharmacological | obesity | trospium | solifenacin | oxybutynin | darifenacin | concomitant medications | polypharmacy | dosage | symptoms | frequency | outcomes
- Shamliyan T, Wyman J, Sainfort F, et al. Nonsurgical Treatments for Urinary Incontinence in Adult Women: Diagnosis and Comparative Effectiveness. Comparative Effectiveness Review No. 36 (Prepared by the Minnesota Evidence-based Practice Center under Contract No. 290-2007-10064-I). Rockville, MD: Agency for Healthcare Research and Quality; April 2012. AHRQ Publication No. 11(12)-EHC074-EF. Available at www.effectivehealthcare.ahrq.gov/ui.cfm.
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