Non-surgical Treatments for Urinary Incontinence in Adult Women: Diagnosis and Comparative Effectiveness
Pharmacological Interventions for UI: Benefits and Adverse Effects
Pharmacological interventions are used for urgency UI and mixed UI. The use of drug treatment for stress UI is rare and is considered “off-label.” In treatment of stress UI with duloxetine, the rate of discontinuation due to adverse effects (125 per 1,000 treated patients) is greater than the rate of benefits (80 per 1,000 treated patients).
In the analyses presented here, benefits are measured as rates of continence or improvement. The rate of discontinuation from treatment due to adverse effects and the rates of individual adverse effects are reported.
- Shamliyan T, Wyman J, Sainfort F, et al. Nonsurgical Treatments for Urinary Incontinence in Adult Women: Diagnosis and Comparative Effectiveness. Comparative Effectiveness Review No. 36 (Prepared by the Minnesota Evidence-based Practice Center under Contract No. 290-2007-10064-I). Rockville, MD: Agency for Healthcare Research and Quality; April 2012. AHRQ Publication No. 11(12)-EHC074-EF. Available at www.effectivehealthcare.ahrq.gov/ui.cfm.
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