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Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults

Slide: 8 of 28

Background: Vagus Nerve Stimulation (VNS)

VNS involves surgically placed electrodes around the left vagus nerve to modulate mood and control seizures. A current of >1 milliamperes and a frequency of 1–145 Hertz is applied for 30 seconds every 5 minutes, generally for 10 weeks. VNS is approved by the FDA for treating TRD; however, availability of this treatment option is limited because its use in the United States is still largely investigational.