Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Background: Nonpharmacologic Interventions
Nonpharmacologic treatments for TRD have included electroconvulsive therapy (ECT) and psychotherapy (only cognitive behavioral therapy or interpersonal therapy were studied for this report), but newer nonpharmacologic approaches have broadened potential options to include repetitive transcranial magnetic stimulation (rTMS) and vagus nerve stimulation (VNS). While rTMS is not approved by the U.S. Food and Drug Administration (FDA) as a treatment for TRD, off-label use for this purpose has been explored.
- Gaynes BN, Lux L, Lloyd S, et al. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33 (Prepared by RTI International–University of North Carolina (RTI-UNC) Evidence-based Practice Center under Contract No. 290-02-0016-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC056-EF. Available at: http://www.effectivehealthcare.ahrq.gov/trd.cfm.
Your slide tray is being processed.