Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Findings of the Comparative Effectiveness Review: Insufficient Evidence
Evidence is insufficient to evaluate the comparative effectiveness or adverse effects between the following comparators:
- ECT versus sham treatment
- rTMS + pharmacotherapy versus pharmacotherapy alone or sham treatment
- Psychotherapy versus control treatment or pharmacotherapy
These results do not suggest that ECT and psychotherapy are ineffective treatments for TRD but merely that data are lacking for these comparisons within the population requirements used for the systematic review.
- Gaynes BN, Lux L, Lloyd S, et al. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33 (Prepared by RTI International–University of North Carolina (RTI-UNC) Evidence-based Practice Center under Contract No. 290-02-0016-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC056-EF. Available at: http://www.effectivehealthcare.ahrq.gov/trd.cfm.
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