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Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults

Slide: 22 of 28

Findings of the Comparative Effectiveness Review: rTMS (1 of 3)

When compared to sham treatment, rTMS demonstrated the following benefits (associated strengths of evidence [SOE] are given in brackets):

  • Greater decrease in depression severity (5+ points on the HAM-D)[High SOE]
  • Three times as likely to produce a response (number needed to treat = 5). [High SOE]
  • Six times as likely to achieve remission of depressive symptoms (number needed to treat = 4). [Moderate SOE]
  • Greater improvement in health status and daily functioning in a mixed MDD/bipolar population. [Low SOE]

Evidence is insufficient to evaluate the ability of rTMS to maintain response or remission.