Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Findings of the Comparative Effectiveness Review: rTMS (1 of 3)
When compared to sham treatment, rTMS demonstrated the following benefits (associated strengths of evidence [SOE] are given in brackets):
- Greater decrease in depression severity (5+ points on the HAM-D)[High SOE]
- Three times as likely to produce a response (number needed to treat = 5). [High SOE]
- Six times as likely to achieve remission of depressive symptoms (number needed to treat = 4). [Moderate SOE]
- Greater improvement in health status and daily functioning in a mixed MDD/bipolar population. [Low SOE]
Evidence is insufficient to evaluate the ability of rTMS to maintain response or remission.
- Gaynes BN, Lux L, Lloyd S, et al. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33 (Prepared by RTI International–University of North Carolina (RTI-UNC) Evidence-based Practice Center under Contract No. 290-02-0016-I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC056-EF. Available at: http://www.effectivehealthcare.ahrq.gov/trd.cfm.
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