Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Findings of the Comparative Effectiveness Review: VNS
In a mixed MDD/bipolar population, evidence of low strength indicates that VNS does not clearly differ from sham treatment with respect to improvements in depression severity, response rates, or daily functioning. However, VNS may produce increased rates of some specific adverse effects (commonly reported adverse effects associated with VNS include voice alteration, cough, neck pain, paresthesia, and dyspnea), and VNS may result in a greater number of withdrawals attributed to adverse events.
- Gaynes BN, Lux L, Lloyd S, et al. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33 (Prepared by RTI International–University of North Carolina (RTI-UNC) Evidence-based Practice Center under Contract No. 290-02-0016I). Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC056-EF. Available at: http://.www.effectivehealthcare.ahrq.gov/trd.cfm
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