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Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults

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Findings of the Comparative Effectiveness Review: ECT Versus Pharmacotherapy

Findings of the Comparative Effectiveness Review: ECT Versus Pharmacotherapy

Evidence of low strength shows that when ECT was compared with paroxetine in a mixed MDD/bipolar population,  ECT produces a greater improvement in depression severity (9 points on the Hamilton Rating Scale for Depression [HAM-D], p = 0.001) and in the treatment response rate (71.4% for ECT vs. 27.8% for paroxetine, p = 0.006).

No other studies evaluating other pharmacotherapies were included in the systematic review, and the adverse event rates of ECT versus pharmacotherapy were not compared in studies.