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Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults

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Outcomes Evaluated by the CER

To examine efficacy and effectiveness (including comparative evaluations), the CER looked at measures of depression severity, response and remission rates, maintenance of remission, improvements to cognitive functioning, and positive health-related outcomes (such as health status and daily functioning).

To examine negative outcomes associated with TRD treatments, the CER looked at measures of adverse events, withdrawals due to adverse events, overall withdrawal rates, deleterious effects on cognitive functioning, and negative effects on health-related outcomes.