Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Clinical Questions Addressed by the CER (1 of 4)
In preparing the report on which this continuing medical education (CME) activity is based, the authors aimed to answer six Key Questions (KQs). KQ 1a is listed below:
KQ 1a: For adults with TRD (defined as two or more failed adequate trials of a biologic intervention), do nonpharmacologic interventions such as ECT, rTMS, VNS, or demonstrated effective psychotherapy (e.g., cognitive therapy [CBT or IPT]) differ in efficacy or effectiveness in treating acute-phase depressive symptoms (e.g., response and remission), whether as a single treatment or part of a combination treatment?
- Gaynes BN, Lux L, Lloyd S, et al. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults. Comparative Effectiveness Review No. 33 (Prepared by RTI International–University of North Carolina (RTI-UNC) Evidence-based Practice Center under Contract No. 290-02-0016-I.) Rockville, MD: Agency for Healthcare Research and Quality; September 2011. AHRQ Publication No. 11-EHC056-EF. Available at: http://www.effectivehealthcare.ahrq.gov/trd.cfm.
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