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Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults

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Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults

This slide set is based on a comparative effectiveness review (CER) titled Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults, which was developed by the RTI International–University of North Carolina (RTI-UNC) Evidence-based Practice Center, Research Triangle Park, North Carolina, for the Agency for Healthcare Research and Quality (AHRQ) under Contract No. 290-02-0016I and is available online at www.effectivehealthcare.ahrq.gov/trd.cfm.

CERs are comprehensive systematic reviews of the literature that usually compare two or more types of treatment with usual care for the same disease. For this CER, the existing body of evidence on the comparative benefits and possible harms of different nonpharmacologic interventions used to treat treatment-resistant depression (TRD) were reviewed. The literature included in this review was identified in searches for trials and studies that included terms for treatment-resistant depression and relevant research designs. Only studies on adults (>18 years of age) were included. Searches were conducted for studies published through November 2010.