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Analgesics for Osteoarthritis—An Update

Slide: 29 of 32

Knowledge Gaps and Future Research Needs (1 of 3)

Nearly all of the clinical trials reviewed in this report were “efficacy” trials conducted in ideal settings and selected populations. “Pragmatic” trials that allow flexible dosing or medication switches and other clinical trials of effectiveness would be very valuable for learning the outcomes of different analgesic interventions in real-world settings.

The CV risks and GI benefits associated with different COX-2 selective NSAIDs may differ. Large, long-term trials with active and placebo-controlled arms would be needed to assess the safety and benefits of any new COX-2 selective analgesic.