Analgesics for Osteoarthritis—An Update
Effects of Adding an H-2 Antagonist, Misoprostol, or a PPI on GI Adverse Effects Associated With NSAIDs (3 of 3)
Celecoxib plus a PPI may reduce the risk of endoscopic ulcers and ulcer complications when compared to celecoxib alone in individuals at average risk.
Strength of evidence: Moderate
When compared with placebo, double-dose H-2 antagonists could be more effective than standard-dose antagonists for reducing endoscopically detected gastric and duodenal ulcers.
Strength of evidence: High
- Chou R, McDonagh M, Nakamoto E, et al. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis: An Update of the 2006 Report. Comparative Effectiveness Review No. 38 (Prepared by Oregon Evidence-based Practice Center under Contract No. HHSA 290-2007-10057-I). Rockville, MD: Agency for Healthcare Research and Quality; October 2011. AHRQ Publication No. 11(12)-EHC076-EF. Available at: http://www.effectivehealthcare.ahrq.gov/reports/analgesicsupdate.cfm.
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