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Analgesics for Osteoarthritis—An Update

Slide: 18 of 32

Comparing Dosage and Duration of Treatment

Higher doses of NSAIDs were associated with greater efficacy for some measures of pain relief and in some trials with greater withdrawals due to adverse effects.
Strength of evidence: High

A meta-analysis of 41 randomized trials found higher doses of celecoxib to be associated with increased risk of CV adverse effects, but there was no clear association between duration of therapy with COX-2 selective NSAIDs and the risk of a CV event.
Strength of evidence: High

Many studies found the risk of GI bleeding increases with higher doses of nonselective NSAIDs, but there was no clear association between duration of therapy with nonselective NSAIDs and the risk of GI bleeding.
Strength of evidence: High