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Analgesics for Osteoarthritis—An Update

Slide: 16 of 32

Comparative Adverse Effects of Oral Agents: GI effects (2 of 2)

The partially selective NSAIDs meloxicam (RR 0.53, 95% CI 0.29 to 0.97) and etodolac (RR 0.32, 95% CI 0.15 to 0.71) were associated with a lower risk of ulcer complications or symptomatic ulcers when compared with nonselective NSAIDs in a systematic review of randomized trials.
Strength of evidence: Moderate

In seven large observational studies, naproxen was associated with a higher risk of serious GI adverse effects than was ibuprofen.
Strength of evidence: High