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Analgesics for Osteoarthritis—An Update

Slide: 15 of 32

Comparative Adverse Effects of Oral Agents: GI Effects (1 of 2)

Acetaminophen could cause elevations of liver enzymes at therapeutic doses even in healthy individuals.
Strength of evidence: Moderate to Low

COX-2 selective NSAIDs as a class were associated with similar, lower risks of ulcer complications relative to the nonselective NSAIDs naproxen (RR 0.34, 95% CI 0.24 to 0.48), ibuprofen (RR 0.46, 95% CI 0.30 to 0.71), and diclofenac (RR 0.31, 95% CI 0.06 to 1.6).
Strength of evidence: High