Analgesics for Osteoarthritis—An Update
Comparative Adverse Effects of Oral Agents: GI Effects (1 of 2)
Acetaminophen could cause elevations of liver enzymes at therapeutic doses even in healthy individuals.
Strength of evidence: Moderate to Low
COX-2 selective NSAIDs as a class were associated with similar, lower risks of ulcer complications relative to the nonselective NSAIDs naproxen (RR 0.34, 95% CI 0.24 to 0.48), ibuprofen (RR 0.46, 95% CI 0.30 to 0.71), and diclofenac (RR 0.31, 95% CI 0.06 to 1.6).
Strength of evidence: High
Keywords: comparative adverse effects | outcomes | strength of evidence | NSAIDs | acetaminophen | GI risk
- Chou R, McDonagh M, Nakamoto E, et al. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis: An Update of the 2006 Report. Comparative Effectiveness Review No. 38 (Prepared by Oregon Evidence-based Practice Center under Contract No. HHSA 290-2007-10057-I). Rockville, MD: Agency for Healthcare Research and Quality; October 2011. AHRQ Publication No. 11(12)-EHC076-EF. Available at: http://www.effectivehealthcare.ahrq.gov/reports/analgesicsupdate.cfm.
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