Clostridium difficile Infections: Diagnosis, Treatment, and Prevention
Limitations of Research on CDI Prevention
The limitations of the research on effective CDI prevention strategies were significant. These studies primarily evaluated effectiveness of CDI prevention during an epidemic or in a hyperendemic environment. The also did not evaluate the sustainability of the interventions beyond the study period. The potential negative impact these interventions would have on the institutional environment other than cost was not evaluated in these studies but may include time needed to perform disinfection; possible harm to surfaces or equipment from harsh decontamination chemicals; failure of vapor disinfection systems; exposure of patients and personnel to toxic chemicals; rates of recontamination after hand washing that results from touching equipment or surfaces in patient rooms contaminated with C. difficile spores, which may persist on some surfaces for up to 5 months; and the reduction in direct patient-care contact due to isolation.
- Butler M, Bliss D, Drekonja D, Filice G, Rector T, MacDonald R, Wilt T. Effectiveness of Early Diagnosis, Prevention, and Treatment of Clostridium difficile Infection. Comparative Effectiveness Review No. 31 (Prepared by the Minnesota Evidence-based Practice Center under Contract No. 290-02-0009.) AHRQ Publication No. 11(12)-EHC051-EF. Rockville, MD. Agency for Healthcare Research and Quality. December 2011. Available at: http://www.effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productID=772.
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