Clostridium difficile Infections: Diagnosis, Treatment, and Prevention
Prevention Strategies for CDI Focusing on Antibiotic Prescribing Policies
Available research found that changes in antimicrobial education, policies, or formularies, which result in decreasing use of high-risk antimicrobials, may be associated with decreased CDI incidence. It was not possible to clearly isolate the impact of the antibiotic-related interventions in the studies examining multiple interventions. In the individual studies, which were usually done in response to outbreaks, interventions in addition to those aimed at antibiotic use may have been done but not reported. The interventions and antibiotics targeted for reduction differed among the various studies. Overall, the strength of evidence was low for these outcomes. The studies reviewed did not evaluate the cost, toxicities, or other related outcomes from the implementation of antibiotic stewardship policies.
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