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Clostridium difficile Infections: Diagnosis, Treatment, and Prevention

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Comparative Effectiveness of CDI Prevention Strategies

Environments of hospitals and outpatient and long-term care facilities involve complex interactions among patients, health care professionals, caregivers, and visitors. CDI-prevention strategies are often implemented or added to existing bundles of infection-control strategies with minimal available evidence. The studies on CDI prevention that were evaluated usually included bundled infection-control interventions making it hard to ascertain the contribution of individual components to the effectiveness of the bundle. Studies that were included examined the effects of prevention strategies aimed at breaking routes of transmission within institutional settings or reducing susceptibility to CDI through antibiotic prescribing practices. Ten studies have examined bundled multiple interventions using before/after study designs. Data was insufficient to draw conclusions. Accurately identifying risk factors associated with CDI can also assist in the implementation of effective prevention strategies.