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Clostridium difficile Infections: Diagnosis, Treatment, and Prevention

Slide: 27 of 33

Overall Conclusions: Nonstandard Interventions to Treat CDI or Reduce the Risk of Recurrence

The conclusions for nonstandard interventions to treat CDI and/or reduce the risk of recurrent infections are limited by the lack of comparative studies available and generally have a low strength of evidence. Current research suggests that:

  • C. difficile immune whey is well tolerated and may prevent recurrence of CDI at rates similar to metronidazole.
  • Fecal flora reconstitution via fecal transplantation may prevent recurrent infections for up to 1 year.
  • Probiotics, prebiotics, and toxin-neutralizing antibodies alone may not reduce CDI incidence rates.
  • An oligofructose prebiotic (low strength of evidence) and toxin-neutralizing antibodies (moderate strength of evidence) have the potential to help reduce the risk of recurrent infections.