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Clostridium difficile Infections: Diagnosis, Treatment, and Prevention

Slide: 18 of 33

Methods Evaluated for Detecting Toxigenic C.difficile

Overall, the reports included data on seven immunoassays for toxins A and B, one two-stage method where an immunoassay for glutamate dehydrogenase was combined with an immunoassay for toxins A and B, and two tests to detect gene fragments involved in the production of toxin B. Only three comparative studies included one of the recently FDA-approved toxin gene detection tests. Thus, the number and type of paired (within study) comparisons available for each diagnostic test varied considerably, and not all possible comparisons were available.