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Clostridium difficile Infections: Diagnosis, Treatment, and Prevention

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Clostridium difficile Infections: Diagnosis, Treatment, and Prevention

This slide set is based on the research presented in a comparative effectiveness review (CER), Effectiveness of Early Diagnosis, Prevention, and Treatment of Clostridium difficile Infection, that was developed by the Minnesota Evidence-based Practice Center for the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-02-0009-EPC2). The findings and conclusions in this document are those of the author(s), who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information presented here is intended to help health care decision makers—clinicians, health system leaders, and policymakers, among others—make well-informed decisions and thereby improve the quality of health care services. This information is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, that is, in the context of available resources and circumstances presented by individual patients.

Several electronic databases (through August 2011), grey literature, trial registries, and reference lists were searched for relevant material. The methods used to develop this CER followed version 1.0 of the Methods Reference Guide for Effectiveness and Comparative Effectiveness Reviews published by AHRQ (draft available at: