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Diagnosis and Treatment of Obstructive Sleep Apnea in Adults

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Adverse Events: Mandibular Advancement Devices

Mandibular advancement devices are associated with the following adverse events: sleep disruption, sensations of pressure in the mouth, mucosal erosions, excessive salivation, dental crown damage, loosening of teeth, and tooth, mouth and jaw pain/damage. Note that adverse-event reporting in the evaluated studies was sparse. The adverse events listed here are evaluated based on cohorts of patients who received specific treatments within each randomized controlled trial, rather than by intertrial comparisons. Furthermore, many studies included short-term outcomes and provided little evidence regarding long-term adverse events.