Diagnosis and Treatment of Obstructive Sleep Apnea in Adults
Correlation of AHI with Health Outcomes
There is a high strength of evidence that an apnea-hypopnea index (AHI) ≥ 30 events per hour (HR, 1.5-3.0) is an independent predictor of all-cause mortality, although one study found that this was true only in men under the age of 70 years. There is a low strength of evidence that a higher AHI (AHI ≥ 8 events per hour, in one study; Botros, 2009) is associated with incident diabetes (OR, 2.81-4.06), though possibly confounded by obesity, which may result in both OSA and diabetes. The strength of evidence is insufficient to determine the association between AHI and other clinical outcomes.
Keywords: AHI | apnea-hypopnea index | correlation | diagnosis | mortality | screening | strength of evidence | outcomes
- Balk EM, Moorthy D, Obadan NO, et al. Diagnosis and Treatment of Obstructive Sleep Apnea in Adults. Comparative Effectiveness Review No. 32 (Prepared by Tufts Evidence-based Practice Center under Contract No. 290-2007-10055-I). Rockville, MD: Agency for Healthcare Research and Quality; July 2011. AHRQ Publication No. 11-EHC052-EF.
- Botros N, Concato J, Mohsenin V, et al. Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med 2009;122:1122-7. PMID: 19958890.
- Reichmuth KJ, Austin D, Skatrud JB, et al. Association of sleep apnea and type II diabetes: a population-based study. Am J Respir Crit Care Med 2005;172:1590-5. PMID: 16192452
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