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Comparative Effectiveness of Therapies for Children With Autism Spectrum Disorders
Gaps in Knowledge
There are no or few studies that describe the following:
- Direct comparisons of the effects of different treatment approaches (e.g., no direct comparison of UCLA/Lovaas and the Early Start Denver Model), and there are few data on practical effectiveness or feasibility beyond research studies.
- Which children are likely to benefit from particular interventions.
- Generalization of treatment effects to contexts outside of the treatment context (e.g., settings), components of multicomponent therapies that drive effectiveness, and predictors of treatment success.
- Which specific treatment approaches to use in children under 2 years of age who are at high risk of developing an ASD based upon behavioral, medical, or genetic risk factors.
- Whether there are any harms associated with behavioral, educational, allied health, or CAM interventions.
- Warren Z, Veenstra V-W, Stone W, et al. Therapies for Children With Autism Spectrum Disorders. Comparative Effectiveness Review No. 26 (Prepared by the Vanderbilt University Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; April 2011. AHRQ Publication No. 11-EHC029-EF.
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