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Comparative Effectiveness of Therapies for Children With Autism Spectrum Disorders

Slide: 27 of 36

Key Question 2: Modifiers of Treatment Outcomes

Few studies were designed or powered to identify modifiers of treatment effect. True treatment modifiers were only demonstrated in one included study. Many other studies failed to find a relationship between autism symptoms and treatment response. The evidence report identified several potential correlates that warrant future study, including: pretreatment IQ and language skills; age at initiation of treatment; social skills, imitation skills, and aloofness (UCLA/Lovaas); and diagnosis.