Traumatic Brain Injury and Depression
Key Question 3 — Prevalence of Concomitant Psychiatric Conditions
Concomitant psychiatric conditions that were included for review were: anxiety disorders, substance abuse, irritability/aggression, and any other disorders named as axis I or axis II disorders in the Diagnostic and Statistical Manual for Mental Disorders. The included studies reported relatively high rates of concomitant psychiatric conditions (8–93% of depressed participants had some concomitant condition), depending on the particular psychiatric condition and the study population and design. However, because few studies presented these data separately for the depressed and nondepressed groups, few conclusions related specifically to this Key Question can be drawn. Anxiety disorders—including general anxiety disorders, PTSD, panic disorder, obsessive-compulsive disorder, and specific phobias—were the most commonly reported coexisting conditions. Most studies grouped these conditions together and reported the overall prevalence of any anxiety disorder (31–61% of study participants in four published studies).
- Guillamondegui OD, Montgomery SA, Phibbs FT, et al. Traumatic Brain Injury and Depression. Comparative Effectiveness Review No. 25 (Prepared by Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I). Rockville, MD: Agency for Healthcare Research and Quality; March 2011. AHRQ Publication No. 11-EHC017-EF. Available at: www.effectivehealthcare.ahrq.gov/reports/final.cfm.
- American Psychiatric Association. Diagnostic and statistical manual for mental disorders. 4th ed. Text revision. Arlington, VA: American Psychiatric Association; 2000.
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