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Traumatic Brain Injury and Depression

Slide: 18 of 25

Key Question 3 — Prevalence of Concomitant Psychiatric Conditions

Concomitant psychiatric conditions that were included for review were: anxiety disorders, substance abuse, irritability/aggression, and any other disorders named as axis I or axis II disorders in the Diagnostic and Statistical Manual for Mental Disorders. The included studies reported relatively high rates of concomitant psychiatric conditions (8–93% of depressed participants had some concomitant condition), depending on the particular psychiatric condition and the study population and design. However, because few studies presented these data separately for the depressed and nondepressed groups, few conclusions related specifically to this Key Question can be drawn. Anxiety disorders—including general anxiety disorders, PTSD, panic disorder, obsessive-compulsive disorder, and specific phobias—were the most commonly reported coexisting conditions. Most studies grouped these conditions together and reported the overall prevalence of any anxiety disorder (31–61% of study participants in four published studies).