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Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer

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Clinical Questions Addressed by the Comparative Effectiveness Review of Radiotherapy for Head and Neck Cancer

Head and neck cancer was defined as tumors of: the larynx; the pharynx (hypopharynx, oropharynx, and nasopharynx); the lips and oral cavity; the paranasal sinus and nasal cavity; the salivary glands; and occult primary of the head and neck. Excluded were: brain tumors; skull base tumors; uveal/choroidal melanoma and other ocular and eyelid tumors; otologic tumors; cutaneous tumors of the head and neck (including melanoma); thyroid cancer; parathyroid cancer; esophageal cancer; and tracheal tumors. Tumor site was not necessarily defined as occurring in one anatomic location. For example, for purposes of data abstraction, “oral cavity” was considered as one site, although it technically involves multiple anatomic sites (e.g., the buccal mucosa, the anterior two-thirds of the tongue, the lips, etc.).