Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Rating the Strength of Evidence From the CER: A Modification of the GRADE Methodology
The system used for rating the strength of the overall body of evidence was developed by AHRQ for the Methods Reference Guide for Effectiveness and Comparative Effectiveness Reviews (version 1.0; available at: http://effectivehealthcare.ahrq.gov/repFiles/2007_10DraftMethodsGuide.pdf) and was based on a method developed by the GRADE (Grading of Recommendations, Assessment, DEvelopment) Working Group. The system used four required domains—risk of bias, consistency, directness, and precision—for assessments. All assessments were made by two investigators who resolved disagreements through discussion. The strength of evidence pertaining to each key question was classified into three broad categories or grades: high, moderate, low, or insufficient.
- Guyatt GH, Oxman AD, Vist GE, et al, for the GRADE Working Group. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008;336:924-6.
- Owens DK, Lohr KN, Atkins D, et al. AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions—Agency for Healthcare Research and Quality and the Effective Health Care Program. J Clin Epidemiol 2010;63:513-23.
- Samson DJ, Ratko TA, Rothenberg BM, et al. Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer, Comparative Effectiveness Review No. 20 (Prepared by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center under Contract No. 290-02-0026). Rockville, MD: Agency for Healthcare Research and Quality; May 2010. AHRQ Publication No. 10-EHC014-EF.
Your slide tray is being processed.