Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Intensity-Modulated Radiation Therapy
IMRT, which has been implemented over the last decade, has further refined radiation dose delivery. IMRT allows the modulation of beam intensity within each field and also enables the use of inverse computer planning, thereby permitting greater control of the dose distribution to the target. With inverse computer planning, the treatment planner defines the tumor target and the normal tissue before a computer algorithm is used to determine beam orientation, the dose to give from each beam, and the amount of modulation to give within each beam. In other words, the computer generates the treatment plan, based on goals defined by the treatment planner.
- Ballivy O, Santamaria RG, Borbalas AL, et al. Clinical application of intensity-modulated radiotherapy for head and neck cancer. Clin Transl Oncol 2008;10:407-14.
- Burri MK, Bevan A, Roach M 3rd. Advances in radiation therapy: conventional to 3D, to IMRT, to 4D, and beyond. CA Cancer J Clin 2005;55:117-34.
- Mendenhall WM, Amdur RJ, Palta JR. Intensity-modulated radiotherapy in the standard management of head and neck cancer: promises and pitfalls. J Clin Oncol 2006;24:2618-23.
- Samson DJ, Ratko TA, Rothenberg BM, et al. Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer, Comparative Effectiveness Review No. 20 (Prepared by the Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center under Contract No. 290-02-0026). Rockville, MD: Agency for Healthcare Research and Quality; May, 2010. AHRQ Publication No. 10-EHC014-EF.
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